Nrf2 activated by salidroside could bind to antioxidant response elements (AREs) such as heme oxygenase-1 (HO-1), SOD, and GSH-Px and could be upregulated to mediate neuroprotection and antioxidative stress in cerebral ischemia (Jin et al., 2019). The gene discussed is HMOX1; the disease is brain ischemia.