In addition, we also found that treatment of MM cells with the SHP099/BTZ combination (BTZ 3 nM for RPMI-8226 or 2 nM BTZ for NCI-H929 combined with 20 μM SHP099) was associated with inferior capability of colony formation than that observed with SHP099 or BTZ alone (Figure 6B). The gene discussed is CASC3; the disease is Miyoshi myopathy.