CRP and hematologic disorder: CRP has been mostly investigated to be associated with VCZ C0 in hematologic malignancy and solid organ transplant patients (42–62 years) (van Wanrooy et al., 2014; Encalada Ventura et al., 2016; Vreugdenhil et al., 2018), and CRP levels are the main risk factor for VCZ overdose in French hematological patients (Gautier-Veyret et al., 2019).