SLC22A13 and gout: In this study, we hypothesized that OAT10 could be a physiologically important machinery involved in the renal urate re-absorption based on our recent study (Higashino et al., 2020), in which clinico-genetic and functional studies revealed that a functionally null variant of OAT10 (c.1129C>T; p.R377C that diminishes the urate transport activity of OAT10 with little effect on its cellular protein level and plasma membrane localization) significantly decreases the risk of gout (odds ratio, OR = 0.67).