Regarding ABCG2 c.421C>A (p.Q141K) that is a well-established gout/hyperuricemia risk allele in the physiologically important urate transporter (Matsuo et al., 2009; Woodward et al., 2009), the calculated β for serum urate in the Japanese males (carriers with ABCG2 421C/A vs. This evidence concerns the gene ABCG2 and gout.