METTL3 and neoplasm: Interestingly, HBXIP also facilitates METTL3 expression by restraining tumor suppressor miRNA let-7g, which stimulates METTL3 expression through targeting its 3′UTR, thereby forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP (Cai et al., 2018).