AKT1 and gastric cancer: Ursolic acid, a natural compound that exists in many herbal plants, is known to obstruct GC progression through the NF-κB pathway (Chen et al., 2020), Hippo pathway (Kim et al., 2019), etc. Berberine has been demonstrated to repress human GC cell growth in vitro and in vivo by inducing cytostatic autophagy via the inhibition of MAPK/mTOR/p70S6K and Akt, ultimately providing a molecular basis for the treatment of GC (Zhang et al., 2020).