With this in mind, the objective of our study was to use discordance analysis to examine the association of apoB with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and TG in early adulthood with concordant or discordant associations with prevalent NAFLD in middle age. Here, APOB is linked to metabolic dysfunction-associated steatotic liver disease.