In addition to VTN, ephrin type-A receptor 4 (EPHA4), belonging to the ephrin receptor subfamily of the protein-tyrosine kinase family, has been implicated in mediating developmental events and associated with the development of SLE, particularly in the central nervous system lupus erythematosus (CNS-SLE) [20, 21]. This evidence concerns the gene EPHA4 and systemic lupus erythematosus.