CDH5 and neoplasm: Vascular endothelial-cadherin (VE-cad), the most important transmembrane component of endothelial adherent junctions, is also related to the formation of vessel-like networks to provide adequate blood supply for tumour growth (Allegrini et al., 2012; Blaise, Polena & Vilgrain, 2015; Irani & Dehghan, 2018; Sulkowska et al., 2006).