A study of ALS indicated that the toxicity mechanism is mediated by GluR2 [Glutamate Ionotropic Receptor α -amino-3-hydroxy-5-methyl-4-isooxazole-propionic acid (AMPA) Type Subunit 2], which plays an important role in both the pathogenesis of sporadic ALS and animal models of superoxide dismutase 1 (SOD1)-related familial ALS (Liu et al., 2018). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.