CFTR and cystic fibrosis: According to our results, the fluid absorption was greater in untreated CFBE (Fig. 2C and D) than 16HBE (Fig. 2A and B) and in primary CF HBE (Fig. 3B) than in wild-type HBE (Fig. 3A), reflecting the expected effect of a dysfunctional CFTR on ENaC.