NUPR1 and neoplasm: In this study, high-sensitivity quantitative label-free quantitative proteomics analysis of formalin-fixed, paraffin-embedded (FFPE) tumour samples was combined with tandem mass tag (TMT) proteomic analysis of the NUPR1 knockdown (KD) OSCC cell line to determine the possible mechanisms of autophagy involved in OSCC proliferation and metastasis.