TFE3 and pancreatic ductal adenocarcinoma: Perera et al. reported that TFE3 enhanced lysosome biogenesis and function and augmented autophagy, which promoted the pathological process of pancreatic ductal adenocarcinoma.18 Moreover, our previous report and other study also confirmed that TFE3, which led to autophagic flux enhancement, was positively correlated with the development and poor prognosis of OSCC as well as breast cancer.12,19