Nuclear protein 1 (NUPR1) is strongly induced by several types of cellular stress and involves in the chromatin remodelling, cell cycle, and apoptosis.12 Importantly, NUPR1 has been demonstrated to facilitate the progression and promotes the metastasis of many malignancies, such as breast cancer, pancreatic adenocarcinoma, hepatocellular cancer and thyroid cancer.12–14 Additionally, emerging evidences have demonstrated that NUPR1 could be taken as an autophagic flux master. The gene discussed is NUPR1; the disease is hepatocellular carcinoma.