The ability of IF to reduce systemic inflammation has been of particular interest, when considering RIF in particular, basic research has shown mostly a positive impact on inflammatory and oxidative stress markers, many of which are involved in the pathogenesis of IBD such as IL-1, TNF-alpha, IL-1 beta, and C-reactive protein (CRP) [8, 9]. The gene discussed is IL1B; the disease is inflammatory bowel disease.