Depression was associated with AD pathology, i.e., lower CSF Aβ42 and higher t-tau and p-tau levels [36], to atrophy of the insula, the inferior frontal lobe, and the limbic neural networks, and to changes in the temporal and parietal regions, including supramarginal, superior and inferior temporal and fusiform gyri, right posterior cingulate and precuneus, locus coeruleus, and basal nucleus of Meynert [22, 35, 44, 47, 53]. The gene discussed is MAPT; the disease is major depressive disorder.