In conclusion, in the present study, we demonstrated that TS could be a target of both miR-215 and miR-375 in PM tumor model; TS modulation by these miRNAs is not associated with response to PEM nor to EMT-marker ZEB1; however, the strong association of both miRNAs and TS expression with PM histotypes and — in epithelioid group — with mesenchymal-like component, suggests that this pathway might drive EMT processes in epithelioid PM. Here, TYMS is linked to neoplasm.