In this study, we evaluated the role of four proteins as biomarkers, still poorly investigated for OC and EC but which have aroused great interest in the context of other tumor diseases: trefoil factor 3 (TFF3), nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-кB), secreted frizzled-related protein 4 (sFRP4), and Reactive Oxygen Species Modulator 1 (Romo-1). This evidence concerns the gene SFRP4 and neoplasm.