Recently, the PURSUIT-HFpEF registry showed a NT-pro BNP before discharge ≥ 1611 pg/mL was a useful marker for hospitalization due to CHF, but its hazard ratio after adjusting covariates was 1.00 (95% CI: 1.00–1.00) in patients who were over 80 years old [16]. This evidence concerns the gene NPPB and congestive heart failure.