ADIPOQ and type 2 diabetes mellitus: According to the weighted-median analysis, genetically high circulating adiponectin played a significant causal role in reduced risk of type 2 diabetes (beta-estimate: −0.030, 95% CI: −0.048 to −0.011, SE:0.009, P-value = 0.002), but it was not supported by IVW analysis (P-value = 0.590) or MR-Egger result (P-value = 0.426, Fig. 1 and Table 2).