ADIPOQ and coronary artery disorder: After excluding these SNP outliers detected by MR-PRESSO method, high circulating adiponectin showed the causal effect on increased risk of coronary artery disease (beta-estimate: 0.012, 95% CI: 0.001 to 0.023, SE:0.006, P-value = 0.030, Fig. 2 and Table 3).