SPOP and colorectal carcinoma: Considering such conditions, we designed the study to explore the function of the CRCSC-derived exosomes (CRCSC-exos) conveying miR-17-5p in CRC development with the involvement of SPOP, and we further speculate that CRCSC-derived exosomal miR-17-7p may target SPOP to regulate the CRC cell growth.