ITGAM and neoplasm: On the other hand, brain and peripheral blood of tumor-bearing control mice were significantly infiltrated by activated neutrophils (CD11b+Ly6G+) and their proportion was remarkably reduced in both brains and blood of anti-Ly6G treated mice that resulted in a significant increase in brain metastasis-free survival compared to control mice (Fig. 2J–L and Supplementary Fig. 2K).