Other autophagy markers including p62 (an adaptor protein for fusion autophagosome and autolysosome degradation) and Beclin-1 (critical for phagophore membrane nucleation) were also induced by penfluridol in ccRCC cell lines (Fig. 2B and Supplementary Fig. 1). The gene discussed is BECN1; the disease is nonpapillary renal cell carcinoma.