BRD4 and neoplasm: Compared with the DM or DM + Sh-NC group, the DM + ShPin1 or DM + JQ1-group tumor tissues exhibited reduced positivity for BRD4, NAP1L1, PCNA, and MMP9, and increased positivity for P21, while JQ1 treatment had no effect on Pin1 expression (Fig. 5i).