PIN1 and Hyperglycemia: To further verify the effect of Pin1/BRD4 axis on lung metastasis of GC induced by hyperglycemia in vivo, luciferase-labeled MKN45 (stably transfected with the sh-NC or shPin1 vector) was introduced into hyperglycemic and normoglycemic nude mice via tail-vein injection, following which DM + JQ1-group mice were treated with JQ1.