FOXO3 and diabetic cardiomyopathy: Interestingly, studies showed that cardiomyocyte pyroptosis was mediated by caspase-11 but not classic caspase-1.179 In diabetic cardiomyopathy, miR-30d targets forkhead box O3 (FOXO3a), which in turn leads to a decrease in ARC, caspase-1 activation, and pyroptosis.180 Activated NLR family pyrin domain containing 3 (NLRP3) inflammasomes and cardiomyocyte pyroptosis can be observed in myocardial tissues from dilated cardiomyopathy patients.