GNA11 and cardiac hypertrophy: MEF2 is released when HDAC leaves the nucleus and activates the transcription of hypertrophic genes.33 Gαq overexpression is sufficient to induce cardiac hypertrophy.34–36 Genetic deletion of Gαq/Gα11 or overexpression of its inhibitory peptide blocks cardiac hypertrophy induced by pressure overload.37–39