In a rat model of myocardial infarction, although acute administration of BQ-123 decreased myocardial contractility, long-term ETA blockade improved rat survival and reduced myocardial remodeling.370 In a heart failure model induced by pressure overload, BQ-123 attenuated cardiac hypertrophy during the early phase.371 Orally active, small-molecule ET receptor antagonists have also been discovered. This evidence concerns the gene EDNRA and heart failure.