NFE2L2 and cardiomyopathy: The iron chelator deferoxamine (DFO) or ferroptosis inhibitor ferrostatin-1 successfully protected the heart from I/R injury.198 In doxorubicin-induced cardiomyopathy, nuclear factor erythroid 2-related factor 2 (NRF2) translocates to the nucleus and upregulates the expression of heme oxygenase 1 (HMOX1), which degrades heme and releases free iron in cardiomyocytes and induces ferroptosis.