MYBPC3 and hypertrophic cardiomyopathy: Recently, a breakthrough was made in human embryos.504 Mutations in the thick filament-associated cardiac myosin-binding protein C (MYBPC3) gene account for approximately 40% of all genetic defects in hypertrophic cardiomyopathy.505 Sperm from an adult male patient with hypertrophic cardiomyopathy caused by a heterozygous dominant 4-bp GAGT deletion in exon 16 of MYBPC3 and oocytes from healthy female donors were studied.