EDN1 and cardiac hypertrophy: In the 1990s, exogenous ET-1 was suggested to have a hypertrophic effect on cultured cardiomyocytes.359–361 Cardiomyocyte-specific overexpression postnatally of ET-1 induced severe cardiac hypertrophy and the rapid deterioration of cardiac function.362 The hypertrophic effect of ET-1 is mostly mediated by increases in DAG.