EGFR and squamous cell carcinoma: In squamous cell carcinomas (SCCs), the SCC-specific SE region co-occupied by TP63 and SOX2 enhances seRNA CCAT1 (colon cancer associated transcript 1) transcription, and the TP63/SOX2/CCAT1 complex promotes tumorigenesis by activating EGFR (epidermal growth factor receptor) transcription [16].