Johnson et al. showed that among 52 patients with BRAF V600E metastatic CRC, the median OS was significantly prolonged when liver resection with curative intent was performed: 29.1 versus 22.7 months, HR 0.33, 95% CI: 0.12–0.78, P = 0.01 [16]. The gene discussed is BRAF; the disease is colorectal carcinoma.