It has been proven by the results from animal experiments by Chen et al. [26] that moxibustion can lower the expression of Rankl mRNA and increase the expression of osteoclastogenesis inhibitory factor (OPG) mRNA, suggesting a recovery of balance between osteoblasts and osteoclasts, based on which moxibustion is considered capable of alleviating cartilage degradation and bone destruction in rabbit rheumatoid arthritis (RA) model possibly through modifying the OPG/RANKL signaling pathway. Here, TNFRSF11B is linked to rheumatoid arthritis.