In total, 15 AD genes were included, i.e., APOE, TOMM40, CR1, DSG2, CD33, CLU, CELF, BIN1, RIN3, PICALM, EPHA1, INPP5D, MEF2C, HLA-DRB5, and HLA-DRB1. This evidence concerns the gene CLU and Alzheimer disease.