95% CI 1.36–2.40, p < 0.001; I2 = 0%; Fig. 2) and GLI (RR: 2.52, 95% CI 1.72–3.68, p < 0.001; I2 = 0%; Fig. 2) were both associated with higher mortality risk in patients with sepsis. Here, GLI1 is linked to Sepsis.