A logistic regression model with Benjamini-Hochberg correction showed that increased levels of PSD-95 and SNAP-25 were observed in early AD as both subjects with MCI and a small number of cognitively unimpaired subjects with positive CSF AD biomarkers (asymptomatic AD, n=6) had increased levels compared to HC (PSD-95 - HC: 130±68 pg/ml; asymptomatic AD: 270±123 pg/ml; pAdj<0.01; AD MCI: 255±116 pg/ml; pAdj<0.00001; SNAP-25 - HC: 97±36 pg/ml; asymptomatic AD: 163±47 pg/ml; pAdj<0.01; AD MCI: 151±51 pg/ml; pAdj=0.00005; Fig. 4C, D). The gene discussed is SNAP25; the disease is Alzheimer disease.