Within the AD group, CSF levels of SNAP-25 and Ng were strongly correlated with CSF levels of tTau (r=0.91 and 0.86, respectively; p<0.0001 for both comparisons) and pTau181 (r=0.81 and 0.69, respectively; p<0.0001 for both comparisons). This evidence concerns the gene SNAP25 and Alzheimer disease.