However, high PSD-95 levels were not specific for AD and subjects with very high PSD-95 levels (defined manually as >650 pg/ml based on levels exceeding the main PSD-95 distribution) were observed in 7 of 62 subjects (11%) with NeuroDegen diseases [frontotemporal dementia (n=3), Lewy body dementia (n=2), and dementia/MCI NOS (n=2)] and in 3 of 59 subjects (5%) with other neurological diseases [CNS vasculitis and multiple strokes (n=1), neurosarcoidosis (n=1), and idiopathic intracranial hypertension (IIH; n=1); Fig. 2B]. This evidence concerns the gene DLG4 and Alzheimer disease.