SNAP25 and Alzheimer disease: SNAP-25 CSF levels were similarly higher in subjects with AD (114±30 pg/ml; Fig. 2C) compared to subjects with NeuroDegen diseases (71±24 pg/ml; p<0.0001), NeuroCtrls (91±53 pg/ml; p<0.005), and HC (83±21 pg/ml; p<0.05).