Levels of PSD-95 and SNAP-25 were nominally higher in AD subjects with dementia (PSD-95: 312±161 pg/ml; SNAP-25: 180±73 pg/ml) compared to MCI in unadjusted analysis (p<0.05 for both comparisons; Fig. 4C, D), but this did not remain statistically significant after multiple testing correction. Here, DLG4 is linked to Alzheimer disease.