Between-group analysis using ANOVA and Tukey’s post hoc test confirmed that AD subjects had higher levels of both PSD-95 (279±138 pg/ml) and SNAP-25 (163±62 pg/ml) compared to HC (PSD-95: 130±68 pg/ml; p<0.00001; SNAP-25: 97±36 pg/ml; p<0.00001), subjects with NeuroDegen diseases (PSD-95: 129±53 pg/ml; p<0.00001; SNAP-25: 79±30 pg/ml; p<0.00001), and NeuroCtrls (PSD-95: 110±38 pg/ml; p<0.00001; SNAP-25: 88±29 pg/ml; p<0.00001). This evidence concerns the gene DLG4 and neurodegenerative disease.