Pro-tumor functions of TAMs include direct secretion of angiogenic growth factors (GFs) leading to an increase in vascular endothelial growth factor (VEGF) [10, 19, 24] and ECM-degrading matrix metalloproteases (MMPs) which allow for the release of ECM-sequestered angiogenic GFs [10, 17]. This evidence concerns the gene VEGFA and neoplasm.