Patients with portal vein thrombosis had higher AFP levels (p = 0.000); patients who had metastasis also had higher AFP levels (p = 0.004); AFP levels in patients with large tumors were significantly higher than those with diffuse or single nodule tumors (p = 0.000); high Child–Pugh score patients had higher AFP levels than those with low scores (p = 0.000); patients with high BCLC stage had higher AFP levels than those with low stages (p = 0.000); similarly, patients with more advanced clinical stages had higher AFP levels than that of lower stages (p = 0.000). Here, AFP is linked to Portal vein thrombosis.