IL1B and neoplasm: ,24 There is also clinical evidence of the prognostic value of CRP in gastrointestinal malignancies.25, 26, 27, 28, 29 Other potential markers of IRT are the neutrophil-to-lymphocytes ratio, cytokines (tumor necrosis factor-α, IL-6, IL-1B, CCL2), or the quantification of lymphocytes subpopulations in the tumor (Immunoscore).30