AMER1 and adenoma: MBD4-deficient adenomas harbored fewer KRAS mutations (three of 19 adenomas) than sporadic tumors (Fisher’s exact, p = 0.0028) but significantly more somatic mutations in AMER1 (MIM: 300647) (12 of 19 adenomas; Fisher’s exact, p = 0.039) (Figure 2F).