First, indirect evidence for metabolic reprogramming during muscle hypertrophy comes from studies that show that cancer metabolic reprogramming factors such as the transcription factor Myc [18] and hypoxia-induced factors, which typically regulate glycolytic genes [19], become more expressed in overloaded hypertrophying mouse muscle (Myc and Hif1a [20]) or in human muscle after a bout of resistance exercise (MYC and EPAS1 [21]). Here, MYC is linked to cancer.