Similarly, both BRC and CAB inhibited ACTH secretion in at least 50% of human corticotroph pituitary tumour primary cultures [19, 23]; importantly, a significant dose-dependent inhibition of ACTH secretion was found after both BRC and CAB administration only in primary cultures expressing D2 receptor, with ACTH response to DAs correlated with D2 receptor expression [23]. This evidence concerns the gene POMC and pituitary tumor.