The major aims of this study were to examine the fundamental fibre-specific abundance and intracellular localization/diffusibility of several key glycogen-related proteins in healthy individuals and people with type 2 diabetes, and to determine whether increased insulin, administered as a hyperinsulinaemic, euglycaemic clamp, alters this expression in skeletal muscle from people with type 2 diabetes. The gene discussed is INS; the disease is type 2 diabetes mellitus.