CD8A and melanoma: We carried out a xenograft model of adoptive cell transfer for the purpose of assessing the influence of Tcf-1 overexpression on the efficacy of TCR-engineered cell-therapy products (Fig. 6A): NSG mice with subcutaneous SK37 melanoma tumors were intravenously injected with CD8+ T cells transduced to express Tcf-1 and the 19,305-TCR.