We recently reported the topically applied NanoFlares (NFs, a nanosensor for intracellular detection of mRNA based on Spherical Nucleic Acid [SNA] platform) for measuring the expression of connective tissue growth factor (CTGF) as a semi‐quantitative indicator of hypertrophic scars and keloids.[11] These optical sensors can diffuse through skin layers, target and quantify cellular mRNA biomarkers, and report the information non‐invasively.[12] Compared with the current visual observation and biopsy‐based methods, the optical methodology is more accurate, timely, convenient, and non‐invasive. The gene discussed is CCN2; the disease is keloid.