This is in line with our previous study showing no effects of APOE4 status or polygenic risk for AD on gray‐matter based brain age in the UK Biobank sample (de Lange, Barth, et al., 2020), as well as a recent UK Biobank study showing that APOE4 genotype was associated with WM hyperintensities, but not with FA or MD in WM tracts (Lyall et al., 2020). Here, APOE is linked to Alzheimer disease.