The ECM turnover involved in homeostatic maintenance and tissue remodeling takes place under physiological (embryonic development, wound healing, tissue repair) and pathological conditions (cancer, inflammation) (Fig. 2), and uPARAP/Endo180 plays its part in this [36], also contributing to the intracellular degradation of collagen with its ability to internalize its fragments. The gene discussed is MRC2; the disease is cancer.