To evaluate the responsiveness to the acute challenge and its potential modulation in terms of redox balance, we analyzed the gene expression of different antioxidant enzymes, i.e., Srxn1, Mt1α, Gpx1, and Gpx4 in three brain regions strongly involved in the stress response, namely the dorsal hippocampus, ventral hippocampus, and prefrontal cortex, whose structure and function are compromised in several stress-related psychiatric disorders. This evidence concerns the gene GPX4 and psychiatric disorder.