KEAP1 and lung carcinoma: We confirmed that KEAP1 deletion markedly increased levels of NRF2 and its transcriptional target SLC7A1138 in H1299 cells (a KEAP1 wild-type [WT] lung cancer cell line) (Fig. 1b and Supplementary Fig. 1a), and correspondingly rendered H1299 cells resistant to ferroptosis induced by erastin (Fig. 1c).