We made similar observations in another KEAP1 WT lung cancer cell line H23 cells: KEAP1 deletion rendered H23 cells resistant to ferroptosis induced by erastin, RSL3, but not FIN56 (Supplementary Fig. 1l–o); SLC7A11 knockdown promoted RSL3- or ML162-induced ferroptosis in H23 cells but not in KEAP1 KO counterparts (Supplementary Fig. 1p–r). Here, SLC7A11 is linked to lung cancer.