In summary, through understanding the mechanistic underpinnings of ferroptosis phenotypes induced by different classes of FINs in KEAP1 deficient lung cancer cells, in this study we identified the CoQ-FSP1 axis as a key downstream effector of the KEAP1-NRF2 pathway to mediate ferroptosis- and radiation-resistance in KEAP1 deficient lung cancers. This evidence concerns the gene NFE2L2 and lung carcinoma.