Importantly, 4-CBA treatment did not exert a radiosensitizing effect or promote RT-induced lipid peroxidation in human bronchial epithelial cells (HBECs) (Fig. 6h, i); therefore, 4-CBA appears to have a more potent ferroptosis-inducing or radiosensitizing effects in KEAP1 inactivated lung cancer cells than in normal lung epithelial cells, suggesting a therapeutic window for the combination therapy with 4-CBA and RT. The gene discussed is KEAP1; the disease is lung cancer.