NFE2L2 and lung carcinoma: This increased capacity to generate NADPH would be critical for buffering the increased NADPH consumption mediated by FSP1 to produce CoQH2, and presumably also contribute to ferroptosis resistance in KEAP1 deficient lung cancer cells, which provide additional insights on why these NADPH-generate enzymes are selected as NRF2 targets and are significantly upregulated in KEAP1 mutant lung cancers48.