Unsupervised clustering analyses revealed positive correlations between the expression of FSP1 and that of many NRF2 target genes in multiple cancers; notably, LUAD and LUSC exhibited the most striking correlations, wherein FSP1 expression positively correlated with most of the NRF2 target genes (Supplementary Fig. 4c, d). The gene discussed is NFE2L2; the disease is cancer.