In this study, we reveal that FSP1, another key arm in ferroptosis surveillance, is also an NRF2 transcriptional target, and its expression is governed by the KEAP1-NRF2 pathway; consequently, FSP1 expression is upregulated in KEAP1 mutant lung cancers (Fig. 7a, b). The gene discussed is AIFM2; the disease is lung cancer.