Correlation analyses of RSL3 EC50 change by iFSP1 with KEAP1 status in this panel of lung cancer cell lines revealed that iFSP1 exhibited more sensitizing effects to RSL3 in KEAP1 WT lung cancer cells than in KEAP1 mutant ones (Supplementary Fig. 3l), which correlates with higher expression levels of FSP1 in KEAP1 mutant lung cancer cells (Supplementary Fig. 3k). This evidence concerns the gene AIFM2 and lung cancer.