Staining of 4-hydroxy-2-noneal (4-HNE), a lipid peroxidation marker51,52, in these tumor samples revealed that KEAP1 deletion decreased 4-HNE staining, which was normalized by FSP1 deletion in KEAP1 deficient tumors (Fig. 4e, f). This evidence concerns the gene AIFM2 and neoplasm.