AIFM2 and neoplasm: While KEAP1 and/or FSP1 deletion did not obviously affect cell proliferation in H1299 cells (Supplementary Fig. 5a), loss of KEAP1 significantly accelerated H1299 xenograft tumor growth, which is consistent with previous reports49,50; importantly, FSP1 deletion markedly suppressed KEAP1 KO tumor growth (Fig. 4c, d).