We confirmed that KEAP1 deletion markedly increased levels of NRF2 and its transcriptional target SLC7A1138 in H1299 cells (a KEAP1 wild-type [WT] lung cancer cell line) (Fig. 1b and Supplementary Fig. 1a), and correspondingly rendered H1299 cells resistant to ferroptosis induced by erastin (Fig. 1c). This evidence concerns the gene NFE2L2 and lung cancer.