Recently, Rana et al. and Zhang et al. published two studies illustrating the important regulatory roles of gasdermin B (GSDMB) and -D (GSDMD) in inflammatory bowel disease (IBD) and intestinal immune homeostasis maintenance, respectively.1,2 Their findings collectively indicate that the gasdermins (GSDMs) can play a crucial role in restoring epithelial barrier function and shaping gut mucosal homeostasis. The gene discussed is GSDMB; the disease is inflammatory bowel disease.