This makes IFNγ even more promising as a potential part of a combinatorial treatment strategy in mCRPC, as it has been shown that decreased membranous expression of E-cadherin is evoked by IFNγ in a Fyn Kinase-dependent manner, and additionally, IFNγ-induced IFIT5 suppresses E-cadherin in prostate cancer via altered miRNA processing26,27. Here, IFNG is linked to Familial prostate cancer.