Moreover, although RARRES2 elevation was positively related to a Chr.7 amplification event possibly owing to its origin gene site in Chr.7 (Supplementary Fig. S2C), the RARRES2 expression level was still a prognostic factor independent of the Chr.7 gain event in GBM patients, as indicated by multivariate Cox analysis (Supplementary Fig. S2D). The gene discussed is RARRES2; the disease is glioblastoma.