Considering that chemerin and TNF-α have been shown to activate NF-κB signaling [33–37], which is an important pathway that regulates the mesenchymal features of glioma [24, 38], we suggest an important role for NF-κB signaling in the chemerin/CMKLR1 axis in GBM. The gene discussed is NFKB1; the disease is central nervous system cancer.