AGO2 and Miyoshi myopathy: In addition, Wu et al. observed that 25 miRNAs, including most let-7 family members and two miR-17-92 cluster members (miR-17a and miR-92-1), were upregulated, and seven miRNAs, including miR-145 and miR-361, were downregulated in Ago2-overexpressing MM cells [11].