In this study, we aimed to decipher whether IGF-IR/PI3K/AKT signaling contributes to aberrant YAP1 activation and to unravel potential cooperative roles of FUS-DDIT3 and YAP1 in MLS tumorigenesis, given previous hints at their nuclear co-localization [15]. This evidence concerns the gene YAP1 and McLeod neuroacanthocytosis syndrome.