IFNG and neoplasm: They found that IFNγ secreted by CD8+ cytotoxic T cells sensitize tumor cells to FIN-induced ferroptosis partly by suppressing the expression of SLC7A11 (Fig. 1); however, IFNγ treatment alone fails to induce obvious ferroptosis in tumor cells.4,5 Reasoning that IFNγ likely needs to cooperate with other factors to induce ferroptosis and considering the intimate link between ferroptosis and lipid metabolism, in this study the authors first tested whether IFNγ can synergize with any fatty acid to trigger ferroptosis in tumor cells.