In a recent study published in Cancer Cell, Liao et al.1 identified CD8+ T-cell-derived interferon (IFN)γ in combination with polyunsaturated fatty acids (PUFAs) as a natural ferroptosis inducer (FIN) to trigger tumor ferroptosis and promote anti-tumor immunity in an acyl-coenzyme A synthetase long-chain family member 4 (ACSL4)-dependent manner. Here, ACSL4 is linked to cancer.