Overall, this study identifies IFNγ (secreted by CD8+ T cells) in combination with AA (taken up from the tumor microenvironment) as a novel natural FIN, and suggests that ACSL4-mediated PUFA-PL synthesis and ferroptosis execution have an important role in anti-tumor immunity.1 This study also raises several intriguing questions for future investigations. The gene discussed is ACSL4; the disease is neoplasm.