It has recently been shown that with lipid-lowering potentiates, activation of the Wnt pathway enhances IL-4 responsiveness in macrophages through the PGE2/STAT3 axis.270 Dickkopf-2 (DKK2), a negative regulator of Wnt/β-catenin, is involved in the activation of macrophages during atherosclerosis. The gene discussed is IL4; the disease is atherosclerosis.