Involvement of Wnt in atherosclerosis was initially found in clinical patients carrying the Wnt co-receptor LRP6 mutation.266 These patients show increased LDL-C, triglycerides, and fasting glucose levels.267,268 Genetic experiments in mice suggest that the function loss of LRP6 is associated with coronary artery disease.267 Similarly, LRP5 also prevents atherosclerosis. This evidence concerns the gene LRP5 and atherosclerosis.