LRP6 and atherosclerosis: Involvement of Wnt in atherosclerosis was initially found in clinical patients carrying the Wnt co-receptor LRP6 mutation.266 These patients show increased LDL-C, triglycerides, and fasting glucose levels.267,268 Genetic experiments in mice suggest that the function loss of LRP6 is associated with coronary artery disease.267 Similarly, LRP5 also prevents atherosclerosis.