Sclerostin, an inhibitor of canonical Wnt pathway, has been identified to prevent atherosclerosis.265 Linking extracellular inhibitor of Wnt/β-catenin signaling sclerostin and DKK1 (Dickkopf-1) to carotid intima-media thickness is recently reported in heart failure with reduced ejection fraction. This evidence concerns the gene SOST and heart failure.