Therefore, PCSK9 inhibitors are new and highly effective functions in lowering lipids.280 Although statins have been widely used, PCSK9 inhibitors are still needed to be used in patients with a high level of cholesterol.281 Because a majority large number of patients receiving statins or in combination with ezetimibe still fail to achieve their therapeutic goals.282 This treatment dilemma is actually exacerbated by the increasing demands on LDL levels in patients with cardiovascular disease.280. The gene discussed is PCSK9; the disease is cardiovascular disorder.