Our previous study found that the cargo profile of exosomes derived from HO-1-modified BMMSCs (HM-exos) changed, which significantly reduced the inflammatory injury of intestinal epithelial cells compared with the exosomes derived from unmodified BMMSCs (M-exos) [19], However, the potential role and mechanism of HO-1/BMMSC-derived exosomes on steatosis-donor liver IRI is unclear. This evidence concerns the gene HMOX1 and steatosis.